Excipients selection for amorphous solid dispersions youtube. Frank romanski, it is important to understand that solid amorphous dispersions are an unique and elegant type of system. Solid dispersion sd, a concept introduced by sekiguchi and obi in the 1960s 11,12, is the. Analysis of the literature and patents on solid dispersions from 1980 to 2015. Supersaturatednonsink and biorelevant dissolution conditions could guide in designing the solid dispersion in order to select optimal polymers, drug loading, and downstream processing for the desired in vivo performance as well as shelf life stability. Analysis of the literature and patents on solid dispersions from. The term solid dispersions has been defined in the early 1970s by chiou and riegelman as a dispersion of an api in an inert carrier in the solid state prepared by solvent, melting or solventmelting methods 10. Amorphous solid dispersions theory and practice navnit. The term amorphous solid dispersion has been used to describe solid mixtures of polymer with amorphous drug. Dissolution of amorphous solid dispersions researchgate. Amorphous solid dispersions theory and practice navnit shah.
Polymeric amorphous solid dispersions journal of pharmaceutical. Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems covers physical and chemical properties, screening, scaleup, formulation, drug product manufacture, intellectual property, and regulatory considerations has an appendix with structure and property information for polymers commonly used in drug development and with marketed drugs developed using the amorphous sold dispersion approach addresses global regulatory. Request pdf dissolution of amorphous solid dispersions. Theory and practice dissolution test is an extremely valuable and powerful tool in understanding.
One can of course argue about the use of the term solid state if amorphous systems are considered. Preparation of amorphous solid dispersions by cryomilling. Theory and practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically. Theory and practice of supersaturable formulations for poorly. Theory and practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future. Mechanisms of increased bioavailability through amorphous solid. Amorphous solid dispersions theory and practice 0dayreleases. Polymerbased amorphous solid dispersions have been considered as the. In twentythree inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, asd technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and asd manufacturing technologies. Amorphous solid dispersions asds can increase the oral.
Sorry, we are unable to provide the full text but you may find it at the following locations. Early reports referred to solid dispersions as mixtures of polymer and crystalline drug. Theory and practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of. Theory and practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly. Spraydried amorphous solid dispersions of atorvastatin. Solid dispersions are an effective formulation technique to improve. The influence of various parameters type of polymer, drug to polymer ratio, ph on the solubility and dissolution rate of the drug was also evaluated.